| Description | The 5' end of eukaryotic and viral mRNAs contain a "cap" structure with
the sequence m7G(5')pppN(5'). The methylation of the 7-position on the
guanine cap is very important to proper mRNA processing and initiation
of translation. The enzyme responsible for this methylation, RNA
guanine-7-methyltransferase, has been cloned and studied from a number
of different species, including human, X. laevis, yeast, and C.
elegans. The sequences for mouse guanine-7-methyltransferase cDNA and
protein have been deduced based upon identity of mouse ESTs to the cDNA
of the human enzyme. The deduced mouse cDNA encodes an ORF of 465 amino
acids and is 76.4% identical to the human enzyme, or 86.5% within the
C-terminal domain. |
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